Parkinson's disease, Alzheimer's disease and motor neurone disease: Identifying a common mechanism

被引:66
作者
Greenfield, S
Vaux, DJ
机构
[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
关键词
acetylcholinesterase; neurodegeneration; amyloid precursor protein; peptide; brainstem nuclei;
D O I
10.1016/S0306-4522(02)00194-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although Alzheimer's disease, Parkinson's disease, and motor neurone disease are distinct disorders, there could be a common neurodegenerative mechanism that characterises the death of selective neurone populations in each case. We propose that this mechanism could be an aberrantly activated, developmental process involving a non-classical, non-enzymatic action of acetylcholinesterase mediated via a short linear motif near the C-terminal end of the molecule. Since this motif has a highly conserved homology with part of the amyloid precursor protein, it may be particularly attractive as a target for novel therapeutic strategies in neurodegeneration. (C) 2002 IBRO. Published by Elsevier Science. Ltd. All rights reserved.
引用
收藏
页码:485 / 492
页数:8
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