Mechanism of superoxide-mediated damage relevance to mitochondrial aging

被引：6

作者：

Afanas'ev, IB ^{[1
]}

机构：

[1] Vitamin Res Inst, Moscow, Russia

来源：

STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE | 2004年 / 1019卷

关键词：

superoxide; mitochondria; hypertensive rats;

D O I：

10.1196/annals.1297.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The damaging effects of superoxide in mitochondria leading to pathological disorders and aging are well documented and usually ascribed to superoxide's role as a precursor of reactive free radical species. However, the latest findings point out the importance of the nucleophilic properties of superoxide and its ability to regulate heterolytic enzymatic processes. Hypothetical mechanisms of superoxide mediation of phosphorylation and dephosphorylation reactions with participation of protein kinases and the apoptotic protein BAD are considered.

引用

页码：343 / 345

页数：3

共 5 条

[1]

Afanasev IB, 1989, SUPEROXIDE ION CHEM, VI

[2]

High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism [J].