Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

被引：9

作者：

Sugimoto, T

Fujii, T

Hatanaka, Y

Yamamura, S

Ueda, M ^{[1
]}

机构：

[1] Keio Univ, Lab Nat Prod, Dept Chem, Fac Sci & Technol, Yokohama, Kanagawa 2238522, Japan

[2] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku, Toyama 93001, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(02)01460-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic Study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin Subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5x10(-5) mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6529 / 6532

页数：4

共 8 条

[1] QUANTITATION OF TRIPLE-HELIX FORMATION USING A PHOTO-CROSS-LINKABLE ARYL AZIDE BIOTIN OLIGONUCLEOTIDE CONJUGATE [J].