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Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

被引：35
作者：
Hernández, JC
León, F
Quintana, J
Estévez, F
Bermejo, J
机构：
[1] Univ La Laguna, Inst Bioorgan Antonio Gonzalez, CSIC, Inst Prod Nat & Agrobiol, E-38206 Tenerife, Spain
[2] ICIC, E-38206 Tenerife, Spain
[3] Univ Las Palmas Gran Canaria, Dept Biochem Mol Biol & Physiol, Las Palmas Gran Canaria 35016, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 16期
关键词：
D O I：
10.1016/j.bmc.2004.06.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 +/- 0.9 muM at 72 h, with growth inhibition caused by the induction of apoptosis, as deter-mined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1. (C) 2004 Elsevier Ltd. All rights reserved.
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页码：4423 / 4429
页数：7
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