The cyclin D1 (CCND1) rs9344 G > A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy

被引：17

作者：

Absenger, G. ^{[1
,2
]}

Benhaim, L. ^{[3
]}

Szkandera, J. ^{[1
,2
]}

Zhang, W. ^{[3
]}

Yang, D. ^{[3
]}

Labonte, M. J. ^{[3
]}

Pichler, M. ^{[1
]}

Stotz, M. ^{[1
,2
]}

Samonigg, H. ^{[1
]}

Renner, W. ^{[2
,4
]}

Gerger, A. ^{[1
,2
]}

Lenz, H-J ^{[3
,5
]}

机构：

[1] Med Univ Graz, Dept Internal Med, Div Clin Oncol, A-8036 Graz, Austria

[2] Med Univ Graz, Res Unit Genet Epidemiol & Pharmacogenet, A-8036 Graz, Austria

[3] Univ So Calif, Keck Sch Med, Div Med Oncol, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[4] Med Univ Graz, Clin Inst Med & Lab Diagnost, A-8036 Graz, Austria

[5] Univ So Calif, Keck Sch Med, USC Ctr Mol Pathways & Drug Discovery, Los Angeles, CA 90033 USA

来源：

PHARMACOGENOMICS JOURNAL | 2014年 / 14卷 / 02期

关键词：

biomarker; CCND1; chemotherapy; colon cancer; polymorphism; SQUAMOUS-CELL CARCINOMA; COLORECTAL-CANCER; RETINOBLASTOMA PROTEIN; GENE POLYMORPHISM; LUNG-CANCER; OVEREXPRESSION; EXPRESSION; SURVIVAL; CETUXIMAB; SMOKING;

D O I：

10.1038/tpj.2013.15

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Recent evidence indicates a potential prognostic and predictive value for germline polymorphisms in genes involved in cell cycle control. We investigated the effect of cyclin D1 (CCND1) rs9344 G>A in stage II/III colon cancer patients and validated the findings in an independent study cohort. For evaluation and validation set, a total of 264 and 234 patients were included. Patients treated with 5-fluorouracil-based chemotherapy, carrying the CCND1 rs9344 A/A genotype had significantly decreased time-to-tumor recurrence (TTR) in univariate analysis and multivariate analysis (hazard ratio (HR) 2.47; 95% confidence interval (Cl) 1.16-5.29; P =0.019). There was no significant association between CCND1 rs9344 G>A and TTR in patients with curative surgery alone. In the validation set, the A allele of CCND1 rs9344 G>A remained significantly associated with decreased TTR in univariate and multivariate analyses (HR 1.94; 95% Cl 1.05-3.58; P =0.035). CCND1 rs9344 G>A may be a predictive and/or prognostic biomarker in stage II/III colon cancer patients, however, prospective trials are warranted to confirm our findings.

引用

页码：130 / 134

页数：5

共 30 条

[1]

Overexpression of cyclin D1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach [J].