CELLULAR OPEN RESOURCE (COR): current status and future directions

被引：41

作者：

Garny, Alan ^{[1
]}

Noble, Denis ^{[1
]}

Hunter, Peter J. ^{[2
]}

Kohl, Peter ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England

[2] Univ Auckland, Auckland Bioengn Inst, Auckland 1142, New Zealand

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2009年 / 367卷 / 1895期

基金：

英国生物技术与生命科学研究理事会;

关键词：

CellML; extensible markup language; markup language; modelling environment; computational biology; HUMAN VENTRICULAR CARDIOMYOCYTES; LATE SODIUM CURRENT; PHYSIOME PROJECT; MODELS; ENVIRONMENT; CELLML; TOOLS;

D O I：

10.1098/rsta.2008.0289

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The need for tools to aid the description and sharing of biological models was highlighted at the launch of the International Union of Physiological Sciences Physiome Project in 1997. This has resulted in the release, in 2001, of the CellML specifications (http://www.cellml.org/speci.cations/). CELLULAR OPEN RESOURCE (COR) was among the early adopters of this standard, eventually forming the first publicly available CellML-based modelling and collaboration environment. From the onset, COR was designed to provide an environment that could not only be used by experienced modellers, but also by experimentalists, teachers and students. It therefore tries to combine a user-friendly interface with a computationally efficient numerical engine. In this paper, we introduce the philosophy behind COR, explain its user interface and current functionality, including the editing and running of CellML files, highlight lessons learned from user feedback and problems experienced during the development of COR and conclude by exploring future development potential.

引用

页码：1885 / 1905

页数：21

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