Association between apolipoprotein E polymorphism, lipids, and coronary artery disease in Tunisian type 2 diabetes

被引：9

作者：

Chaaba, Raja ^{[1
]}

Attia, Nebit ^{[1
]}

Hammami, Sonia ^{[2
]}

Smaoui, Maha ^{[1
]}

Ben Hamda, Khaldoun ^{[3
]}

Mahjoub, Sylvia ^{[2
]}

Hammami, Mohamed ^{[1
]}

机构：

[1] CHU Monastir, Fac Med, Biochem Lab, Monastir 5019, Tunisia

[2] CHU Monastir, Dept Internal Med, Monastir 5019, Tunisia

[3] CHU Monastir, Dept Cardiol, Monastir 5019, Tunisia

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2008年 / 2卷 / 05期

关键词：

Apolipoprotein E; Coronary artery disease; LDL cholesterol; Triglycerides; Type; 2; diabetes;

D O I：

10.1016/j.jacl.2008.08.441

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND: The relationship between apolipoprotein E (ApoE) polymorphism, fasting lipid parameters, and coronary artery disease (CAD) is controversial. METHODS: We studied this relationship, for the first time, in Tunisian type 2 diabetic patients. The studied population comprised 157 type 2 diabetic patients (145 of them were not on any lipid-lowering drugs). Fasting lipids were measured by enzymatic methods and ApoE genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Our results showed that the alleles E2, E3, and E4 were found in 4%, 88%, and 8% of patients, respectively. In the total type 2 diabetic population, no association was found between ApoE polymorphism. lipid parameters, and CAD. However, the E4 allele was associated with elevated low-density lipoprotein cholesterol concentration and with CAD in type 2 diabetic men. CONCLUSION: The effect of ApoE polymorphism on CAD is gender-dependent in the Tunisian type 2 diabetic population. ApoE 4 allele may enhance atherogenesis indirectly by a strong effect on low-density lipoprotein cholesterol. (C) 2008 National Lipid Association. All rights reserved.

引用

页码：360 / 364

页数：5

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