Dopamine transporters and cognitive function in methamphetamine abuser after a short abstinence: A SPECT study

被引:58
作者
Chou, Yuan-Hwa
Huang, Wen-Sheng
Su, Tung-Ping
Lu, Ru-Band
Wan, Fang-Jung
Fu, Ying-Kay
机构
[1] Taipei Vet Gen Hosp, Dept Psychiat, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Taipei 112, Taiwan
[3] Tri Serv Gen Hosp, Dept Nucl Med, Taipei, Taiwan
[4] Natl Def Med Ctr, Taipei, Taiwan
[5] Natl Cheng Kung Univ, Inst Behav Med, Coll Med & Hosp, Taipei, Taiwan
[6] Natl Cheng Kung Univ, Dept Psychiat, Coll Med & Hosp, Taipei, Taiwan
[7] Tri Serv Gen Hosp, Dept Psychiat, Taipei, Taiwan
[8] Inst Nucl Energy Res, Tao Yuan, Taiwan
关键词
single photon emission computed tomography; methamphetamine; dopamine transporter; Wisconsin Card Sorting Test;
D O I
10.1016/j.euroneuro.2006.05.002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The purpose of this study was to examine the change of dopamine transporters (DAT) binding in methamphetamine (METH) abusers in a two-week period of abstinence and its association with cognitive function. Seven healthy subjects and seven METH abusers were recruited. At baseline conditions, the values of specific uptake ratio (SUR) of DAT binding measured by single photon emission computed tomography were lower in METH abusers than in controls. After a two-week period of abstinence, DAT binding was partially recovered and there were no statistic differences in SUR between METH abusers and controls. There was a borderline correlation between the changes of DAT binding in the right, but not the left, striatum and the %Error of Wisconsin Card Sorting Test. These findings indicate that DAT binding in METH abusers can be reversed in a short period of abstinence. The recovery of DAT binding was asymmetric and possibly parallel with the improvement of cognitive function. (c) 2006 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码:46 / 52
页数:7
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