A comparison between methods for linkage disequilibrium fine mapping of quantitative trait loci

被引：10

作者：

Abdallah, JM

Mangin, B

Goffinet, B

Cierco-Ayrolles, C

Pérez-Enciso, M

机构：

[1] INRA, Stn Ameliorat Genet Anim, F-31326 Castanet Tolosan, France

[2] INRA, Unite Biometrie & Intelligence Artificielle, F-31326 Castanet Tolosan, France

来源：

GENETICAL RESEARCH | 2004年 / 83卷 / 01期

关键词：

D O I：

10.1017/S0016672303006554

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present a maximum likelihood method for mapping quantitative trait loci that uses linkage disequilibrium information from single and multiple markers. We made paired comparisons between analyses using a single marker, two markers and six markers. We also compared the method to single marker regression analysis under several scenarios using simulated data. In general, our method outperformed regression (smaller mean square error and confidence intervals of location estimate) for quantitative trait loci with dominance effects. In addition, the method provides estimates of the frequency and additive and dominance effects of the quantitative trait locus.

引用

页码：41 / 47

页数：7

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