Wnt/PCP signaling:: A veritable polar star in establishing patterns of polarity in embryonic tissues

被引：69

作者：

Barrow, Jeffery R. ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Physiol & Dev Biol, Provo, UT 84602 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 02期

关键词：

Wnt/planar cell polarity; embryonic patterning; vertebrate;

D O I：

10.1016/j.semcdb.2006.04.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Embryonic patterning has traditionally been viewed as the establishment of spatially significant gene expression in response to secreted signals. Recent work has highlighted the role of the Wnt/planar cell polarity (PCP) pathway in patterning tissues. Rather than establishing characteristic arrays of gene expression, however, this pathway functions to institute uniform polarity of cells within a tissue. Cells thus polarized can undergo directed migrations, cell divisions, etc., which are essential for normal morphogenesis. In this review, I will highlight the similarities between mechanisms that establish patterns of polarity between Drosophila and vertebrates. Further, I will discuss recent advances with regard to Wnt/PCP signaling in vertebrates. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：185 / 193

页数：9

共 81 条

[1] Mathematical modeling of planar cell polarity to understand domineering nonautonomy [J].

Amonlirdviman, K ;

Khare, NA ;

Tree, DRP ;

Chen, WS ;

Axelrod, JD ;

Tomlin, CJ .

SCIENCE, 2005, 307 (5708) :423-426

[2] Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain [J].

Ashery-Padan, R ;

Alvarez-Bolado, G ;

Klamt, B ;

Gessler, M ;

Gruss, P .

MECHANISMS OF DEVELOPMENT, 1999, 80 (02) :213-217

[3] The orientation of cell divisions determines the shape of Drosophila organs [J].

Baena-López, LA ;

Baonza, A ;

García-Bellido, A .

CURRENT BIOLOGY, 2005, 15 (18) :1640-1644

[4] The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila [J].

Bellaïche, Y ;

Beaudoin-Massiani, O ;

Stüttem, I ;

Schweisguth, F .

DEVELOPMENT, 2004, 131 (02) :469-478

[5] Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division [J].

Bellaïche, Y ;

Gho, M ;

Kaltschmidt, JA ;

Brand, AH ;

Schweisguth, F .

NATURE CELL BIOLOGY, 2001, 3 (01) :50-57

[6] Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction [J].

Belteki, G ;

Haigh, J ;

Kabacs, N ;

Haigh, K ;

Sison, K ;

Costantini, F ;

Whitsett, J ;

Quaggin, SE ;

Nagy, A .

NUCLEIC ACIDS RESEARCH, 2005, 33 (05) :1-10

[7] The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs [J].

Castillejo-López, C ;

Arias, WM ;

Baumgartner, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (23) :24034-24043

[8]

Chae J, 1999, DEVELOPMENT, V126, P5421

[9] The zebrafish Nodal signal Squint functions as a morphogen [J].

Chen, Y ;

Schier, AF .

NATURE, 2001, 411 (6837) :607-610

[10]

Concha ML, 1998, DEVELOPMENT, V125, P983

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