Bioactivation of titanium surfaces using coatings of TiO2 nanotubes rapidly pre-loaded with synthetic hydroxyapatite

被引：213

作者：

Kodama, A. ^{[2
]}

Bauer, S. ^{[1
]}

Komatsu, A. ^{[2
]}

Asoh, H. ^{[2
]}

Ono, S. ^{[2
]}

Schmuki, P. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Mat Sci, WW4 LKO, D-91058 Erlangen, Germany

[2] Kogakuin Univ, Dept Appl Chem, Tokyo 1920015, Japan

来源：

ACTA BIOMATERIALIA | 2009年 / 5卷 / 06期

关键词：

TiO2; nanotubes; Hydroxyapatite; Simulated body fluid; Anodization; Alternative immersion method; ANODIC POROUS ALUMINA; BIOMIMETIC APATITE; SELF-ORGANIZATION; GROWTH; OXIDATION; ANODIZATION;

D O I：

10.1016/j.actbio.2009.02.032

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Apatite depositions from simulated body fluid (SBF) have been widely used for the in vitro assessment of the bioactivity of bone- and dental-implant materials. In previous work, we reported that titanium-based implant materials can be coated with an anodic TiO2 nanotube layer which can significantly stimulate apatite formation. In the present work, we demonstrate that the tubular nature of such coatings makes them highly suitable for the application of a treatment called "alternative immersion method (AIM)", which preloads the coatings with synthetic hydroxyapatite. This treatment is indeed found to additionally promote natural apatite formation significantly. To study the AIM effect, layers of nanotubes with various diameters and crystal structures (amorphous, anatase/rutile) were produced, AIM-treated, and the formation of apatite in SBF10 (10 mmol l(-1) HCO3-) was evaluated. The results show a drastic enhancement of apatite deposition rates (in some cases >20-fold acceleration) for AIM-treated TiO2 nanotube layers in comparison with non-treated TiO2 surfaces. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：2322 / 2330

页数：9

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