Gene mapping by linkage and association analysis

被引：35

作者：

March, RE ^{[1
]}

机构：

[1] Astra Zeneca, Res & Dev Genet Dept, Macclesfield, Cheshire, England

来源：

MOLECULAR BIOTECHNOLOGY | 1999年 / 13卷 / 02期

关键词：

human genetics; genetic analysis; linkage; allelic association; linkage disequilibrium; computer program;

D O I：

10.1385/MB:13:2:113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic analysis is used to map genes, including disease loci, to positions within the human genome. Linkage analysis depends on the co-segregation of a gene (locus) and a phenotype through a pedigree, while association analysis, or linkage disequilibrium mapping, depends on measuring deviation from the random occurrence of alleles in a haplotype in unrelated individuals or nuclear families. Complex computer programs may be used in both forms of analysis. In recent years most interest has focused on identifying genes involved in common, multifactorial diseases. Here I review some current and developing techniques of genetic analysis and give references to where further information can be obtained.

引用

页码：113 / 122

页数：10

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