The cortical vibrissae representation is normal in transgenic mice lacking the 5-HT1B receptor

被引：5

作者：

Boylan, CB ^{[1
]}

Kesterson, KL ^{[1
]}

Crnko-Hoppenjans, TA ^{[1
]}

Ke, M ^{[1
]}

Rizk, T ^{[1
]}

Mooney, RD ^{[1
]}

Rhoades, RW ^{[1
]}

机构：

[1] Med Coll Ohio, Dept Anat & Neurobiol, Toledo, OH 43614 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2000年 / 120卷 / 01期

关键词：

serotonin; 5-HT1B receptor; transgenic knockout mouse; somatosensory cortex; barrel; cytochrome oxidase;

D O I：

10.1016/S0165-3806(99)00194-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies have suggested that 5-HT may modulate thalamocortical development in somatosensory cortex (S-I) of rats and mice, and that the 5-HT1B receptor may play a critical role in this process. Analysis of CO-stained sections through lamina IV of S-I in perinatal and adult 5-HT1B knockout mice revealed a normal vibrissae-related pattern, indicating that activation of the 5-HT1B receptor is not necessary for the normal development of the vibrissae representation in S-I. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：91 / 93

页数：3

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