Control of Sindbis virus infection by antibody in interferon-deficient mice

被引：54

作者：

Byrnes, AP

Durbin, JE

Griffin, DE

机构：

[1] Johns Hopkins Med Inst, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[2] Ohio State Univ, Childrens Hosp, Res Fdn, Columbus, OH 43205 USA

[3] Ohio State Univ, Dept Pediat, Columbus, OH 43205 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 08期

关键词：

D O I：

10.1128/JVI.74.8.3905-3908.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon, Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

引用

页码：3905 / 3908

页数：4

共 20 条

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