Probiotic and prebiotic supplementation for the prevention of neonatal necrotizing enterocolitis

被引：34

作者：

Caplan, M. S. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Pediat, Evanston, IL USA

来源：

JOURNAL OF PERINATOLOGY | 2009年 / 29卷

关键词：

necrotizing enterocolitis; probiotics; prebiotics; inflammatory necrosis; LOW-BIRTH-WEIGHT; DOUBLE-BLIND; INTESTINAL PERFORATION; INFANTS; RAT; PATHOGENESIS; PRETERM; GROWTH; OLIGOSACCHARIDES; MICROFLORA;

D O I：

10.1038/jp.2009.21

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The pathophysiology of necrotizing enterocolitis (NEC) has not been clearly elucidated, but recent studies support the role of unbalanced pro-inflammatory signaling, leading to intestinal necrosis in premature infants. Although breast milk feeding is thought to reduce the risk of this condition, there are no preventive or therapeutic approaches that have consistently shown to be effective for this common and devastating disease. Recent studies show that probiotic colonization is abnormal in preterm neonates, and enteral supplementation with a variety of probiotic organisms can reduce the risk of disease. This chapter summarizes the current state-of-the-art regarding probiotics and NEC, but suggests caution until appropriately regulated products are available for use in this high-risk population. Journal of Perinatology (2009) 29, S2-S6; doi:10.1038/jp.2009.21

引用

页码：S2 / S6

页数：5

共 40 条

[1] Toll-like receptor signaling [J].

Akira, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) :38105-38108

[2]

Akira S, 2003, BIOCHEM SOC T, V31, P637, DOI 10.1042/BST0310637

[3] Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial [J].

Besselink, Marc G. H. ;

van Santvoort, Hjalmar C. ;

Buskens, Erik ;

Boermeester, Marja A. ;

van Goor, Harry ;

Timmerman, Harro M. ;

Nieuwenhuijs, Vincent B. ;

Bollen, Thomas L. ;

van Ramshorst, Bert ;

Witteman, Ben J. M. ;

Rosman, Camiel ;

Ploeg, Rutger J. ;

Brink, Menno A. ;

Schaapherder, Alexander F. M. ;

Dejong, Cornelis H. C. ;

Wahab, Peter J. ;

van Laarhoven, Cees J. H. M. ;

van der Harst, Erwin ;

van Eijck, Casper H. J. ;

Cuesta, Miguel A. ;

Akkermans, Louis M. A. ;

Gooszen, Hein G. .

LANCET, 2008, 371 (9613) :651-659

[4] Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates [J].

Bin-Nun, A ;

Bromiker, R ;

Wilschanski, M ;

Kaplan, M ;

Rudensky, B ;

Caplan, M ;

Hammerman, C .

JOURNAL OF PEDIATRICS, 2005, 147 (02) :192-196

[5] Impact of necrotizing enterocolitis on length of stay and hospital charges in very low birth weight infants [J].

Bisquera, JA ;

Cooper, TR ;

Berseth, CL .

PEDIATRICS, 2002, 109 (03) :423-428

[6] Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: Outcomes through 18 months adjusted age [J].

Blakely, ML ;

Tyson, JE ;

Lally, KP ;

McDonald, S ;

Stoll, BJ ;

Stevenson, DK ;

Poole, WK ;

Jobe, AH ;

Wright, LL ;

Higgins, RD .

PEDIATRICS, 2006, 117 (04) :E680-E687

[7] Prebiotics in infant formulas [J].

Boehm, G ;

Jelinek, J ;

Stahl, B ;

van Laere, K ;

Knol, J ;

Fanaro, S ;

Moro, G ;

Vigi, V .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2004, 38 (06) :S76-S79

[8] SERUM PAF ACETYLHYDROLASE INCREASES DURING NEONATAL MATURATION [J].

CAPLAN, M ;

HSUEH, W ;

KELLY, A ;

DONOVAN, M .

PROSTAGLANDINS, 1990, 39 (06) :705-714

[9] NECROTIZING ENTEROCOLITIS - A REVIEW OF PATHOGENETIC MECHANISMS AND IMPLICATIONS FOR PREVENTION [J].

CAPLAN, MS ;

MACKENDRICK, W .

PEDIATRIC PATHOLOGY, 1993, 13 (03) :357-369

[10] HYPOXIA, PAF, AND NECROTIZING ENTEROCOLITIS [J].

CAPLAN, MS ;

SUN, XM ;

HSUEH, W .

LIPIDS, 1991, 26 (12) :1340-1343

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