Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus

被引：244

作者：

Kim, HM ^{[1
]}

Han, SB ^{[1
]}

Oh, GT ^{[1
]}

Kim, YH ^{[1
]}

Hong, DH ^{[1
]}

Hong, ND ^{[1
]}

Yoo, ID ^{[1
]}

机构：

[1] HAN KOOK SIN YAK PHARM CO LTD,BONG CHON NAT PROD RES INST,TAEJON 302243,SOUTH KOREA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1996年 / 18卷 / 05期

关键词：

Phellinus linteus; polysaccharide; cell mediated immunity; humoral immunity;

D O I：

10.1016/0192-0561(96)00028-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polysaccharide was purified from mycelial culture of Phellinus linteus (PL) and its effect on immunocompetence of normal splenocytes was observed. Overall in vitro and in vivo immune function was enhanced by addition of PL into culture of mouse spleen lymphocyte and I.p. injection into mouse, while S-glucans and other polysaccharides only raised the level of T lymphocyte-mediated immunity. PL stimulated immune functions of T lymphocytes, such as proliferation of T lymphocyte induced by mixed lymphocyte reaction and cytotoxicity of cytotoxic T cells responding to alloantigen. Nonspecific immune functions mediated by natural killer cells and macrophages were increased by treatment of PL in vivo and in vitro. PL also stimulated humoral immune function positively, such as T-dependent and T-independent primary antibody responses, and acted as a polyclonal activator on B cell. PL exhibited a wider range of immunostimulation and antitumor activity than other polysaccharides isolated from Basidiomycetes. Copyright (C) 1996 International Society for Immunopharmacology

引用

页码：295 / 303

页数：9

共 30 条

[1] ARIKA T, 1983, P 13 INT C CHEM, V238, P53
[2] TRANSIENT EXPRESSION OF INTERLEUKIN-2 RECEPTORS - CONSEQUENCES FOR T-CELL GROWTH
CANTRELL, DA
SMITH, KA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (06) : 1895 - 1911
[3] CHIHARA G, 1983, ADV EXP MED BIOL, V166, P189
[4] CHIHARA G, 1984, REV IMMUNOL IMMUNOPH, V4, P48
[5] DELVES PJ, 1992, ENCY IMMUNOLOGY, P903
[6] FIDLER IJ, 1985, CANCER RES, V45, P4714
[7] FRANZ G, 1989, PLANTA MED, V55, P493
[8] FURUE H, 1987, Drugs of Today, V23, P335
[9] Goldsmith M. A., 1994, CYTOKINE HDB, P65
[10] Hamuro J, 1984, IMMUNE MODULATION AG, P409

← 1 2 3 →