Pain facilitatory circuits in the mammalian central nervous system: their behavioral significance and role in morphine analgesic tolerance

被引：59

作者：

McNally, GP ^{[1
]}

机构：

[1] Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1999年 / 23卷 / 08期

关键词：

hyperalgesia; antianalgesia; analgesia; tolerance; fear; learned safety; illness; pavlovian conditioning;

D O I：

10.1016/S0149-7634(99)00040-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Sensitivity to noxious stimulation is not invariant; rather, it is modulated by discrete pain inhibitory and facilitatory circuits. This paper reviews the neural circuits for pain facilitation, describes the conditions governing their environmental activation, and examines their role in an animal's behavioral repertoire. Mechanisms for pain facilitation are contrasted at both the neural and behavioral level with mechanisms for pain inhibition. In addition, the involvement of mechanisms for pain facilitation in morphine analgesic tolerance is discussed, and the implications of this involvement for accounts of the role of associative processes in analgesic tolerance an highlighted. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1059 / 1078

页数：20

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