Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection

被引:86
作者
Zhang, ZQ [1 ]
Fu, TM [1 ]
Casimiro, DR [1 ]
Davies, ME [1 ]
Liang, XP [1 ]
Schleif, WA [1 ]
Handt, L [1 ]
Tussey, L [1 ]
Chen, MC [1 ]
Tang, AM [1 ]
Wilson, KA [1 ]
Trigona, WL [1 ]
Freed, DC [1 ]
Tan, CY [1 ]
Horton, M [1 ]
Emini, EA [1 ]
Shiver, JW [1 ]
机构
[1] Merck Res Labs, Dept Viral Vaccine Res, W Point, PA 19486 USA
关键词
D O I
10.1128/JVI.76.24.12845-12854.2002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Expression of several major histocompatibility complex (MHC) class I alleles is associated with a protective effect against disease progression in both human immunodeficiency virus type I and simian immunodeficiency virus infection. To understand the mechanism underlying this effect, we investigated the expression of the MHC class I allele Mamu-A*01 in simian-human immunodeficiency virus (SHIV) infection, one of the major models for evaluation of AIDS vaccine candidates. We found that disease progression was significantly delayed in Mamu-A*01-positive rhesus monkeys infected with the highly pathogenic SHIV 89.6P. The delay corresponded not only to a noted Mamu-A*01-restricted dominant cytotoxic T-lymphocyte (CTL) response but also to a lower viral load in lymph nodes (LN) and, importantly, to minimal destruction of LN structure during early infection. In contrast, Mamu-A*01-negative monkeys exhibited massive destruction of LN structure with accompanying rapid disease progression. These data indicate that MHC class I allele-restricted CTL responses may play an important role in preservation of lymphoid tissue structure, thereby resulting in attenuation of disease progression in immunodeficiency virus infection.
引用
收藏
页码:12845 / 12854
页数:10
相关论文
共 37 条
[1]   Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].
Amara, RR ;
Villinger, F ;
Altman, JD ;
Lydy, SL ;
O'Neil, SP ;
Staprans, SI ;
Montefiori, DC ;
Xu, Y ;
Herndon, JG ;
Wyatt, LS ;
Candido, MA ;
Kozyr, NL ;
Earl, PL ;
Smith, JM ;
Ma, HL ;
Grimm, BD ;
Hulsey, ML ;
Miller, J ;
McClure, HM ;
McNicholl, JM ;
Moss, B ;
Robinson, HL .
SCIENCE, 2001, 292 (5514) :69-74
[2]   Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].
Barouch, DH ;
Santra, S ;
Schmitz, JE ;
Kuroda, MJ ;
Fu, TM ;
Wagner, W ;
Bilska, M ;
Craiu, A ;
Zheng, XX ;
Krivulka, GR ;
Beaudry, K ;
Lifton, MA ;
Nickerson, CE ;
Trigona, WL ;
Punt, K ;
Freed, DC ;
Guan, LM ;
Dubey, S ;
Casimiro, D ;
Simon, A ;
Davies, ME ;
Chastain, M ;
Strom, TB ;
Gelman, RS ;
Montefiori, DC ;
Lewis, MG ;
Emini, EA ;
Shiver, JW ;
Letvin, NL .
SCIENCE, 2000, 290 (5491) :486-492
[3]   HLA and HIV-1:: Heterozygote advantage and B*35-Cw*04 disadvantage [J].
Carrington, M ;
Nelson, GW ;
Martin, MP ;
Kissner, T ;
Vlahov, D ;
Goedert, JJ ;
Kaslow, R ;
Buchbinder, S ;
Hoots, K ;
O'Brien, SJ .
SCIENCE, 1999, 283 (5408) :1748-1752
[4]   VARIABLE COURSE OF PRIMARY SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN LYMPH-NODES - RELATION TO DISEASE PROGRESSION [J].
CHAKRABARTI, L ;
CUMONT, MC ;
MONTAGNIER, L ;
HURTREL, B .
JOURNAL OF VIROLOGY, 1994, 68 (10) :6634-6643
[5]   HLA class I alleles associated with susceptibility or resistance to human immunodeficiency virus type 1 infection among a population in Chaco Province, Argentina [J].
de Sorrentino, AH ;
Marinic, K ;
Motta, P ;
Sorrentino, A ;
López, R ;
Illiovich, E .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (05) :1523-1526
[6]   Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression [J].
Dykhuizen, M ;
Mitchen, JL ;
Montefiori, DC ;
Thomson, J ;
Acker, L ;
Lardy, H ;
Pauza, CD .
JOURNAL OF GENERAL VIROLOGY, 1998, 79 :2461-2467
[7]   ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTED TISSUES BY AMPLIFICATION AND INSITU HYBRIDIZATION REVEALS LATENT AND PERMISSIVE INFECTIONS AT SINGLE-CELL RESOLUTION [J].
EMBRETSON, J ;
ZUPANCIC, M ;
BENEKE, J ;
TILL, M ;
WOLINSKY, S ;
RIBAS, JL ;
BURKE, A ;
HAASE, AT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :357-361
[8]   Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV [J].
Evans, DT ;
Knapp, LA ;
Jing, PC ;
Mitchen, JL ;
Dykhuizen, M ;
Montefiori, DC ;
Pauza, CD ;
Watkins, DI .
IMMUNOLOGY LETTERS, 1999, 66 (1-3) :53-59
[9]   Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: Evidence for an influence on disease progression [J].
Evans, DT ;
Jing, PC ;
Allen, TM ;
O'Connor, DH ;
Horton, H ;
Venham, JE ;
Piekarczyk, M ;
Dzuris, J ;
Dykhuzen, M ;
Mitchen, J ;
Rudersdorf, RA ;
Pauza, CD ;
Sette, A ;
Bontrop, RE ;
DeMars, R ;
Watkins, DI .
JOURNAL OF VIROLOGY, 2000, 74 (16) :7400-7410
[10]   MULTIFACTORIAL NATURE OF HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE - IMPLICATIONS FOR THERAPY [J].
FAUCI, AS .
SCIENCE, 1993, 262 (5136) :1011-1018