Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach

被引：18

作者：

Aviles-Jimenez, F

Letley, DP

Gonzalez-Valencia, G

Salama, N

Torres, J

Atherton, JC ^{[1
]}

机构：

[1] Univ Nottingham Hosp, Wolfson Digest Dis Ctr, Nottingham NG7 2UH, England

[2] Univ Nottingham Hosp, Inst Infect Immun & Inflammat, Nottingham NG7 2UH, England

[3] IMSS, Mexico City, DF, Mexico

[4] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98104 USA

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 15期

关键词：

D O I：

10.1128/jb.186.15.5182-5185.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity.

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页码：5182 / 5185

页数：4

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