The splenic toxicity of water soluble multi-walled carbon nanotubes in mice

被引：76

作者：

Deng, Xiaoyong ^{[1
]}

Wu, Fei ^{[1
]}

Liu, Zhen ^{[1
]}

Luo, Man ^{[2
]}

Li, Ling ^{[1
]}

Ni, Qingshun ^{[1
]}

Jiao, Zheng ^{[1
]}

Wu, Minghong ^{[1
]}

Liu, Yuanfang ^{[1
,3
]}

机构：

[1] Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China

[2] Fudan Univ, ZhongShan Hosp, Dept Gerontol, Shanghai 200032, Peoples R China

[3] Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

来源：

CARBON | 2009年 / 47卷 / 06期

关键词：

IN-VIVO; PULMONARY TOXICITY; GENE DELIVERY; PLASMID DNA; BIODISTRIBUTION; CELLS; CYTOTOXICITY; TRANSPORTERS; TRANSLOCATION; NANOPARTICLES;

D O I：

10.1016/j.carbon.2008.12.032

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Spleen is an important immune organ and a constituting part of the reticuloendothelial system (RES). CNTs in vivo can be readily scavenged from blood and mainly entrapped by liver, spleen and lungs. Herein, water soluble multi-walled carbon nanotubes (S-MWCNTs) were used as a model to investigate the possible toxicity of carbon nanotubes (CNTs) to mouse spleen. The toxicity of various doses of S-MWCNTs was examined by carbon clearance measurement, oxidative stress assay, histopathologic and electron-microscopic examination. Compared with the control group, phagocytic activity of RES, activity of reduced glutathione, superoxide dismutase and malondialdehyde in splenic homogenate did not change significantly in 2 months. The histopathologic examination showed no observable sign of damage in spleen; however, the accumulated S-MWCNTs gradually transferred from the red pulp to the white pulp over the exposure time and might initiate the adaptive immune response of spleen. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1421 / 1428

页数：8

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