Matrix metalloproteinases in tumor invasion

被引：352

作者：

Johansson, N

Ahonen, M

Kähäri, VM

机构：

[1] Univ Turku, MediCity Res Lab, FIN-20520 Turku, Finland

[2] Univ Turku, Dept Biochem Med, FIN-20520 Turku, Finland

[3] Univ Turku, Turku Ctr Biotechnol, Turku, Finland

[4] Univ Turku, Cent Hosp, Dept Dermatol, FIN-20520 Turku, Finland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2000年 / 57卷 / 01期

关键词：

squamous cell carcinoma; invasion; matrix; metalloproteinase;

D O I：

10.1007/s000180050495

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Controlled degradation of extracellular matrix (ECM) is essential for the growth, invasion, and metastasis of malignant tumors, and for tumor-induced angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases collectively capable of degrading essentially all ECM components and they apparently play an important role in all these aspects of tumor development. Furthermore, recent evidence suggests that MMPs also play a role in tumor cell survival. In this review, we discuss the current concept concerning the role of MMPs and their inhibitors in tumor invasion, as a basis for prognosis and targeted therapeutic intervention cancer.

引用

页码：5 / 15

页数：11

共 155 条

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