Rab37 is a novel mast cell specific GTPase localized to secretory granules

被引：64

作者：

Masuda, ES

Luo, Y

Young, C

Shen, M

Rossi, AB

Huang, BCB

Yu, S

Bennett, MK

Payan, DG

Scheller, RH

机构：

[1] Rigel Inc, S San Francisco, CA 94080 USA

[2] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

FEBS LETTERS | 2000年 / 470卷 / 01期

关键词：

GTPase; exocytosis; mast cell; allergy;

D O I：

10.1016/S0014-5793(00)01288-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GTPases regulate a myriad of cellular functions including signal transduction, cytoskeletal organization and membrane trafficking. Rab GTPases act to coordinate the membrane dynamics of cells by organizing and regulating the activity of effector proteins important in vesicle trafficking. Rab37 is a novel Rab GTPase specifically expressed in the MC-9 mast cell line and bone marrow mast cells, Rab37 is 74% identical to Rab26 and 47% identical to Rabs, a GTPase important in Golgi to plasma membrane vesicle trafficking in mammalian cells, When green fluorescent protein tagged Rab37 is expressed in bone marrow mast cells, the secretory granules are labeled. These data suggest that Rab37 may play an important role in mast cell degranulation making this protein a potentially important target for therapeutic intervention in the treatment of allergy. (C) 2000 Federation of European Biochemical Societies.

引用

页码：61 / 64

页数：4

共 11 条

[1] SNARE proteins mediate lipid bilayer fusion [J].