CA-125 and CRP are Elevated in Preeclampsia

被引：47

作者：

Cebesoy, Fatma Bahar ^{[1
]}

Balat, Ozcan ^{[1
]}

Dikensoy, Ebru ^{[1
]}

Kalayci, Hakan ^{[1
]}

Ibar, Yelda ^{[1
]}

机构：

[1] Gaziantep Univ, Fac Med, Dept Obstet & Gynecol, TR-27060 Gaziantep, Turkey

来源：

HYPERTENSION IN PREGNANCY | 2009年 / 28卷 / 02期

关键词：

CRP; CA-125; Preeclampsia; Eclampsia; C-REACTIVE PROTEIN; PREGNANT-WOMEN; CA125; SERUM;

D O I：

10.1080/10641950802601187

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. Methods: The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were used to monitor the severity of disease. CRP and CA-125 levels were determined. The cut-offs for CRP and CA-125 were 5 mg/L and 35 IU/ml. The t-test, Pearson correlation and ANOVA were used for statistical analysis. Values of p 0.05 were considered to be significant. Results: CRP and CA-125 parameters were significantly higher in the study group (p 0.001), and were significantly higher in severe preeclampsia and eclampsia groups than in mild preeclampsia (p 0.001). Significant correlations were found between CRP/MAP, CRP/albumin, CA-125/MAP and CA-125/albumin (p 0.001). Conclusion: CRP and CA-125 are elevating markers in preeclampsia.

引用

页码：201 / 211

页数：11

共 20 条

[1]

ACOG Committee on Obstetric Practice, 2002, Int J Gynaecol Obstet, V77, P67

[2] Maternal serum CA125 and CA15-3 antigen levels in normal and pathological pregnancy [J].

Bon, GG ;

Kenemans, P ;

Verstraeten, AA ;

Go, S ;

Philipi, PA ;

van Kamp, GJ ;

van Geijn, HP ;

van Vugt, JMG .

FETAL DIAGNOSIS AND THERAPY, 2001, 16 (03) :166-172

[3] CA125 production by the peritoneum: in-vitro and in-vivo studies [J].

Epiney, M ;

Bertossa, C ;

Weil, A ;

Campana, A ;

Bischof, P .

HUMAN REPRODUCTION, 2000, 15 (06) :1261-1265

[4]

HALILA H, 1986, CANCER-AM CANCER SOC, V57, P1327, DOI 10.1002/1097-0142(19860401)57:7<1327::AID-CNCR2820570713>3.0.CO

[5]

2-Z

[6]

HORNSTEIN MD, 1992, FERTIL STERIL, V58, P279

[7] Maternal serum highly sensitive C-reactive protein in normal pregnancy and pre-eclampsia [J].

Hwang, H. S. ;

Kwon, J. Y. ;

Kim, M. A. ;

Park, Y. W. ;

Kim, Y. H. .

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2007, 98 (02) :105-109

[8]

JAGER W, 1987, FERTIL STERIL, V48, P675

[9] MEASUREMENT OF CEA, TPA, NEOPTERIN, CA125, CA153 AND CA199 IN SERA OF PREGNANT-WOMEN, UMBILICAL-CORD BLOOD AND AMNIOTIC-FLUID [J].

LELLE, RJ ;

HENKEL, E ;

LEINEMANN, D ;

GOESCHEN, K .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1989, 27 (03) :137-142

[10] Elevated CA125 level associated with Meigs' syndrome:: case report and review of the literature [J].

Morán-Mendoza, A ;

Alvarado-Luna, G ;

Calderillo-Ruiz, G ;

Serrano-Olvera, A ;

López-Graniel, CM ;

Gallardo-Rincón, D .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2006, 16 :315-318

← 1 2 →