CD4+CD25+Foxp3+ T cells and CD4+CD'25-Foxp3+ T cells in aged mice

被引:172
作者
Nishioka, Tomohisa
Shimizu, Jun
Iida, Ryuji
Yamazaki, Sayuri
Sakaguchi, Shimon
机构
[1] Natl Inst Longev Sci, Immunol Sect, Dept Mech Aging, Natl Ctr Geriatr & Gerontol, Aichi 4748522, Japan
[2] Nara Inst Sci & Technol, Div Gene Funct Anim, Grad Sch Biol Sci, Nara, Japan
[3] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto, Japan
[4] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Kawaguchi, Japan
关键词
D O I
10.4049/jimmunol.176.11.6586
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Aging is associated with a progressive decline in T cell-mediated immune responses. However, it has been unknown whether regulatory/suppressive CD4 T cells are involved in this decline. Our in vitro analyses revealed that CD4(+) CD25(+) T cells, the well-characterized naturally occurring regulatory/suppressive CD4 T cells, in aged mice are functionally comparable to those in young mice (i.e., anergic and suppressive), although slightly increased in number. In contrast, functional changes to whole CD4(+)CD25(-) T cells were pronounced in aged mice, i.e., the majority of aged CD4(+)CD25(-) T cells exhibited a significant hyporesponsiveness, and the remaining cells maintained a normal responsiveness. Furthermore, we identified Foxp3 (a transcription factor critical in conferring the regulatory/suppressive function to CD4 T cells)-positive suppressive CD4 T cells among aged hyporesponsive CD4(+)CD25(-) T cells. These results suggest that the age-related decline in T cell-mediated immune responses is ascribable to changes in the CD4(+)CD25(-) T cell population and not to a functional augmentation of suppressive CD4(+)CD25(+) T cells.
引用
收藏
页码:6586 / 6593
页数:8
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