Suppression of translation frameshift by upstream termination codon

被引：6

作者：

Honda, A ^{[1
]}

Nishimura, S ^{[1
]}

机构：

[1] MERCK RES LABS, BANYU TSUKUBA RES INST, TSUKUBA, IBARAKI 30033, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 221卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0642

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retroviruses employ translation frameshift for gene expression. Translation frameshift takes place at the slippery heptanucleotide sequence on mRNA. A downstream stem-loop structure (and a pseudoknot formed by the stem-loop) enhances the level of ribosomal frameshifting. Here, we describe that an upstream termination codon suppresses the ribosomal frameshifting, leading to reduction in the expression of downstream genes. (C) 1996 Academic Press, Inc.

引用

页码：602 / 608

页数：7

共 21 条

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