Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

被引：357

作者：

Eltzschig, Holger K. ^{[1
]}

Bratton, Donna L. ^{[2
]}

Colgan, Sean P. ^{[3
]}

机构：

[1] Univ Colorado, Sch Med, Dept Anesthesiol, Organ Protect Program, Aurora, CO 80045 USA

[2] Natl Jewish Hlth, Dept Pediat, Denver, CO 80206 USA

[3] Univ Colorado, Sch Med, Dept Med, Mucosal Inflammat Program, Aurora, CO 80045 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2014年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

INDUCIBLE FACTOR-I; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; SINGLE-NUCLEOTIDE POLYMORPHISMS; PAS DOMAIN PROTEIN; DNA-BINDING; FACTOR (HIF)-1; HIF-1-DEPENDENT REPRESSION; TRANSCRIPTIONAL REGULATION; ECTO-5'-NUCLEOTIDASE CD73;

D O I：

10.1038/nrd4422

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes associated with disorders such as inflammatory bowel disease, pathogen infection and acute lung injury, as well as during ischaemia-reperfusion injury. HIF stabilization and hypoxia-induced changes in gene expression have a profound impact on the inflamed tissue microenvironment and on disease outcomes. Although the mechanism that initiates HIF stabilization may vary, the final molecular steps that control HIF stabilization converge on a set of oxygen-sensing prolyl hydroxylases (PHDs) that mark HIFs for proteasomat degradation. PHDs are therefore promising therapeutic targets. In this Review, we discuss the emerging potential and associated challenges of targeting the PHD-HIF pathway for the treatment of inflammatory and ischaemic diseases.

引用

页码：852 / 869

页数：18

共 223 条

[1]

Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis [J].

Aherne, Carol M. ;

Collins, Colm B. ;

Masterson, Joanne C. ;

Tizzano, Marco ;

Boyle, Theresa A. ;

Westrich, Joseph A. ;

Parnes, Jason A. ;

Furuta, Glenn T. ;

Rivera-Nieves, Jesus ;

Eltzschig, Holger K. .

GUT, 2012, 61 (05) :695-705

[2]

The resurgence of A2B adenosine receptor signaling [J].

Aherne, Carol M. ;

Kewley, Emily M. ;

Eltzschig, Holger K. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2011, 1808 (05) :1329-1339

[3]

Adenosine A2A receptor is a unique angiogenic target of HIF-2α in pulmonary endothelial cells [J].

Ahmad, Aftab ;

Ahmad, Shama ;

Glover, Louise ;

Miller, Stacy M. ;

Shannon, John M. ;

Guo, Xiaoling ;

Franklin, Wilbur A. ;

Bridges, James P. ;

Schaack, Jerome B. ;

Colgan, Sean P. ;

White, Carl W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (26) :10684-10689

[4]

HIF-1 expression in healing wounds:: HIF-1α induction in primary inflammatory cells by TNF-α [J].

Albina, JE ;

Mastrofrancesco, B ;

Vessella, JA ;

Louis, CA ;

Henry, WL ;

Reichner, JS .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2001, 281 (06) :C1971-C1977

[5]

Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair - A randomized controlled trial [J].

Ali, Ziad A. ;

Callaghan, Chris J. ;

Lim, Eric ;

Ali, Ayyaz A. ;

Nouraei, S. A. Reza ;

Akthar, Asim M. ;

Boyle, Jonathan R. ;

Varty, Kevin ;

Kharbanda, Rajesh K. ;

Dutka, David P. ;

Gaunt, Michael E. .

CIRCULATION, 2007, 116 (11) :I98-I105

[6]

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism [J].

Aragones, Julian ;

Schneider, Martin ;

Van Geyte, Katie ;

Fraisl, Peter ;

Dresselaers, Tom ;

Mazzone, Massimiliano ;

Dirkx, Ruud ;

Zacchigna, Serena ;

Lemieux, Helene ;

Jeoung, Nam Ho ;

Lambrechts, Diether ;

Bishop, Tammie ;

Lafuste, Peggy ;

Diez-Juan, Antonio ;

Harten, Sarah K. ;

Van Noten, Pieter ;

De Bock, Katrien ;

Willam, Carsten ;

Tjwa, Marc ;

Grosfeld, Alexandra ;

Navet, Rachel ;

Moons, Lieve ;

Vandendriessche, Thierry ;

Deroose, Christophe ;

Wijeyekoon, Bhathiya ;

Nuyts, Johan ;

Jordan, Benedicte ;

Silasi-Mansat, Robert ;

Lupu, Florea ;

Dewerchin, Mieke ;

Pugh, Chris ;

Salmon, Phil ;

Mortelmans, Luc ;

Gallez, Bernard ;

Gorus, Frans ;

Buyse, Johan ;

Sluse, Francis ;

Harris, Robert A. ;

Gnaiger, Erich ;

Hespel, Peter ;

Van Hecke, Paul ;

Schuit, Frans ;

Van Veldhoven, Paul ;

Ratcliffe, Peter ;

Baes, Myriam ;

Maxwell, Patrick ;

Carmeliet, Peter .

NATURE GENETICS, 2008, 40 (02) :170-180

[7]

Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity [J].

Asikainen, Tiina M. ;

Chang, Ling-Yi ;

Coalson, Jacqueline J. ;

Schneider, Barbara K. ;

Waleh, Nahid S. ;

Ikegami, Machiko ;

Shannon, John M. ;

Winter, Vicki T. ;

Grubb, Peter ;

Clyman, Ronald I. ;

Yoder, Bradley A. ;

Crapo, James D. ;

White, Carl W. .

FASEB JOURNAL, 2006, 20 (10) :1698-+

[8]

Type 1 diabetes [J].

Atkinson, Mark A. ;

Eisenbarth, George S. ;

Michels, Aaron W. .

LANCET, 2014, 383 (9911) :69-82

[9]

Perioperative Organ Injury [J].

Bartels, Karsten ;

Karhausen, Joern ;

Clambey, Eric T. ;

Grenz, Almut ;

Eltzschig, Holger K. .

ANESTHESIOLOGY, 2013, 119 (06) :1474-1489

[10]

Hypoxia and inflammation are two sides of the same coin [J].

Bartels, Karsten ;

Grenz, Almut ;

Eltzschig, Holger K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (46) :18351-18352

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