Homocysteine and risk of developing hypertension in men

被引：29

作者：

Bowman, T. S. ^{[1
]}

Gaziano, J. M.

Stampfer, M. J.

Sesso, H. D.

机构：

[1] Massachusetts Vet Affairs Epidemiol Res & Inform, Vet Affairs Boston Healthcare Syst, Boston, MA USA

[2] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

JOURNAL OF HUMAN HYPERTENSION | 2006年 / 20卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/sj.jhh.1002052

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In cross-sectional studies, elevated homocysteine levels are associated with higher blood pressure, but it remains unclear whether plasma homocysteine is a risk factor for hypertension. In a prospective nested case-control study, participants who developed hypertension (n=396) had significantly higher levels of baseline plasma homocysteine (12.6 mu mol/l) than matched controls (11.8 mu mol/l, P=0.03); compared to those in the lowest quintile, those in the highest quintile had a crude relative risk (RR) of 1.56 (95% confidence interval (CI), 0.98-2.48; P for trend=0.10) and a multivariable RR of 1.63 (95% CI, 0.97-2.74; P for trend=0.13). Higher plasma homocysteine levels at baseline were associated with an increased but non-significant risk of incident hypertension that was minimally affected by multivariable adjustment.

引用

页码：631 / 634

页数：4

共 12 条

[11] Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey, 1988-1994 [J].