Aminomethylpyridines as DPP-IV inhibitors

被引：24

作者：

Peters, JU ^{[1
]}

Weber, S ^{[1
]}

Kritter, S ^{[1
]}

Weiss, P ^{[1
]}

Wallier, A ^{[1
]}

Zimmerli, D ^{[1
]}

Boehringer, M ^{[1
]}

Steger, M ^{[1
]}

Loeffler, BM ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, Div Pharma, CH-4070 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 13期

关键词：

D O I：

10.1016/j.bmcl.2004.04.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a novel series of DPP-IV inhibitors, a large increase of inhibitory activity was achieved by optimisation of aromatic substituents and conformational restriction. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3579 / 3580

页数：2

共 18 条

[1] Dipeptidyl peptidase IV inhibitors as new therapeutic agents for the treatment of Type 2 diabetes [J].

Augustyns, K ;

Van der Veken, P ;

Senten, K ;

Haemers, A .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2003, 13 (04) :499-510

[2]

BOEHRINGER M, 2003, Patent No. 0368748

[3]

BOEHRINGER M, 2003, Patent No. 0368757

[4] The entero-insular axis in type 2 diabetes - incretins as therapeutic agents [J].

Creutzfeldt, W .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2001, 109 :S288-S303

[5] Enhancing incretin action for the treatment of type 2 diabetes [J].

Drucker, DJ .

DIABETES CARE, 2003, 26 (10) :2929-2940

[6] Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes [J].

Drucker, DJ .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (01) :87-100

[7] GLUCAGONLIKE PEPTIDE-I STIMULATES INSULIN GENE-EXPRESSION AND INCREASES CYCLIC-AMP LEVELS IN A RAT ISLET CELL-LINE [J].

DRUCKER, DJ ;

PHILIPPE, J ;

MOJSOV, S ;

CHICK, WL ;

HABENER, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) :3434-3438

[8] MAB, A GENERALLY APPLICABLE MOLECULAR-FORCE FIELD FOR STRUCTURE MODELING IN MEDICINAL CHEMISTRY [J].

GERBER, PR ;

MULLER, K .

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1995, 9 (03) :251-268

[9] Incretin hormones - an update [J].

Holst, JJ ;

Orskov, C .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2001, 61 :75-85

[10]

KAMBE S, 1980, SYNTHESIS-STUTTGART, P366

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