Bacterial replication in the host cell cytosol

被引：55

作者：

Goebel, W ^{[1
]}

Kuhn, M ^{[1
]}

机构：

[1] Univ Wurzburg, Lehrstuhl Mikrobiol, Theodor Boveri Inst Biowissensch, D-97074 Wurzburg, Germany

来源：

CURRENT OPINION IN MICROBIOLOGY | 2000年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1369-5274(99)00050-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intracellular bacteria in mammalian host cells can either live in a membrane-bound vacuole modified to support bacterial growth, or escape from the primary phagosome into the host cell cytoplasm. Phagosomal escape is best studied in Listeria monocytogenes in which a pore-forming cytolysin and two phospholipases are involved in the lysis of the phagosomal membrane. The mechanisms of and requirements for cytoplasmic growth are less clear but there is growing evidence that proficient replication of bacteria in the cytoplasmic compartment requires specific bacterial and cellular preconditions.

引用

页码：49 / 53

页数：5

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