Hypoglycemia in patients with renal failure

被引:51
作者
Haviv, YS [1 ]
Sharkia, M [1 ]
Safadi, R [1 ]
机构
[1] Hebrew Univ Jerusalem, Med Ctr, Dept Pediat, IL-91120 Jerusalem, Israel
关键词
hypoglycemia; chronic renal failure;
D O I
10.1081/JDI-100100866
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Of a total of 1545 admissions of end stage renal failure (ESRD) patients, fifty-six (3.6%) were admitted during a ten-year period with hypoglycemia. Thirty-eight of them were diabetic while the others were nondiabetic patients. The most common etiology found to be drug-induced hypoglycemia in 26 (46%) patients. In 22 (39%) cases, sepsis was the contributing cause of hypoglycemia. Severe malnutrition caused 7% of hypoglycemic episodes. Of the patients, 18 (32%) with ESRD eventually died, none of them were from the drug induced group. However, mortality rate in the sepsis induced hypoglycemia group was 66%, and of the malnutrition group 17% of the deaths. Thus, hypoglycemia is frequent in ESRD patients, and is fatal if associated with either sepsis or malnutrition.
引用
收藏
页码:219 / 223
页数:5
相关论文
共 11 条
  • [1] Adrogue H.J., Glucose homeostasis and the kidney, Kidney Int, 42, pp. 1266-1282, (1992)
  • [2] DeFronzo R.A., Andres R., Edgar P., Walker U.G., Carbohydrate metabolism in uremia: A review, Medicine, 52, pp. 469-481, (1973)
  • [3] DeFronzo R.A., Tobin J.D., Rowe J.U., Andres R., Glucose intolerance in uremia, J Chin Invest, 62, pp. 425-435, (1978)
  • [4] Gerich J.E., Campbell P.J., Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions, Diab Metab Rev, 4, pp. 93-111, (1988)
  • [5] Owen O.E., Felig P., Morgan A.P., Wahren J., Cahill G.F. Jr., Liver and kidney metabolism during prolonged starvation, J Chin Invest, 48, pp. 574-583, (1969)
  • [6] Cohen J.J., Barac-Nieto M., Renal metabolism of substrates in relation to renal function, Handbook of Physiology, pp. 909-1001, (1973)
  • [7] Adrogue H.J., Comstock J.P., Pena J., Hartley C., Entman M., Rashad M.N., Large renal glucose production in conscious diabetic dogs without acidosis, Diabetes, 39, (1990)
  • [8] Adrogue H.J., Pena J., Comstock J.P., Net glucose production and extraction of insulin/glucagon by the kidney in normal conscious dogs, Clin Res, 39, (1991)
  • [9] Jenssen T., Norjhan N., Consoli A., Gerich J.E., Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans, J Clin Invest, 86, pp. 489-497, (1990)
  • [10] Fishcer K.F., Lees J.A., Newman J.H., Hypoglycemia in hospitalized patients: Causes and outcomes, N Eng J Med, 315, pp. 1245-1250, (1986)