Dynamic behavior of glucose-responsive poly(methacrylic acid-g-ethylene glycol) hydrogels

被引：149

作者：

Hassan, CM ^{[1
]}

Doyle, FJ ^{[1
]}

Peppas, NA ^{[1
]}

机构：

[1] PURDUE UNIV,SCH CHEM ENGN,BIOMAT & DRUG DELIVERY LAB,W LAFAYETTE,IN 47907

来源：

MACROMOLECULES | 1997年 / 30卷 / 20期

关键词：

D O I：

10.1021/ma970117g

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Glucose-sensitive poly(methacrylic acid-g-ethylene glycol) (P(MAA-g-EG)) gels were synthesized by copolymerizing methacrylic acid and poly(ethylene glycol) monomethacrylate in the presence of activated glucose oxidase. The dynamic and equilibrium swelling behavior of the gels was examined as a function of pH. At low pH values the gels were in a collapsed state due to complexation between carboxyl and etheric groups. At high pH values, the gels swelled to approximately 20 times their dry weights. The glucose oxidase containing gels exhibited a higher rate of expansion than the non glucose oxidase containing gels as the former had fewer entanglements. Relaxation times were determined for the swelling and deswelling processes, and a time-dependent swelling behavior was obtained for partial swellings in different pH values.

引用

页码：6166 / 6173

页数：8

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