Cascaded z-filters for efficient single-scan suppression of zero-quantum coherence

A simple and robust method to suppress zero-quantum coherence (ZQC) in NMR experiments, in a single scan and with very high suppression ratio, is described. It is an appreciable improvement on a previous technique by Thrippleton and Keeler [Angew. Chem. Int. Ed. 42 (2003) 3938]. The method, called a z-filter cascade, preserves longitudinal, or z-magnetization, with high efficiency. Losses depend mostly on T-1 relaxation but not T-2 relaxation mechanisms. At the same time, suppression of ZQC can be essentially complete in a single scan. The time duration of the z-filter cascade scales inversely to representative chemical shift differences between the coupled spins, and is typically a few tens of milliseconds. The high efficiency of the zero-quantum suppression and excellent retention of the desired z-magnetization, in a single scan without resort to phase cycling or difference spectroscopy, makes the z-filter cascade a useful new pulse sequence building block for a whole range of NMR experiments. In cases where unwanted residual ZQC may have previously contributed to baseline "t(1)-noise" in two-dimensional NMR spectra, the z-filter cascade can deliver a noteworthy improvement in spectral quality. (C) 2004 Elsevier Inc. All rights reserved.