Rapid method for the analysis of itraconazole and hydroxyitraconazole in serum by high-performance liquid chromatography

被引：42

作者：

Compas, D

Touw, DJ

deGoede, PNFC

机构：

[1] Lab. of the Pharmacy Department, Univ. Hospital Vrije Universiteit, 1007 MB Amsterdam

来源：

JOURNAL OF CHROMATOGRAPHY B | 1996年 / 687卷 / 02期

关键词：

itraconazole; hydroxyitraconazole;

D O I：

10.1016/S0378-4347(96)00245-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An assay for the determination of itraconazole and its active metabolite hydroxyitraconazole in serum has been developed, using ketoconazole as internal standard. The procedure involved a one-step liquid-liquid extraction of the drug, its metabolite and the internal standard, followed by their separation by reversed-phase HPLC. In this paper the validation of this method is described.

引用

页码：453 / 456

页数：4

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