Is mechano-sensitive expression of twist involved In mesoderm formation?

被引：19

作者：

Brouzés, E ^{[1
]}

Supatto, W ^{[1
]}

Farge, E ^{[1
]}

机构：

[1] Univ Paris 07, Mecan & Genet Dev Embryonnaire, Grp Physicochi,Curie, UMR 168,Inst Curie, F-75005 Paris, France

来源：

BIOLOGY OF THE CELL | 2004年 / 96卷 / 07期

关键词：

mechanical induction; development; twist; snail; cancer;

D O I：

10.1016/j.biolcel.2004.04.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesoderm invagination, the first morphogenetic movement of gastrulation in the early Drososphila embryo, is controlled by the expression of the twist and snail genes. Our knowledge concerning epistatic relationships between these genes implies the existence of a poorly understood biochemical maintenance of twist expression during mesoderm invagination by the snail gene. In the light of a review detailing the role of these genes in the cell shape changes leading to invagination, and of recent findings showing the expression of twist as mechanically sensitive, we suggest that the expression of twist in the mesoderm could alternatively be maintained by mechanical strains developed during mesoderm invagination. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：471 / 477

页数：7

共 41 条

[1] The rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation [J].