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Altered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus:: The road from anergy to autoimmunity

被引：3
作者：
Blasini, AM
Rodríguez, MA
机构：
[1] Hosp Univ Caracas, Div Rheumatol, Ctr Nacl Enfermedades Reumat, Caracas, Venezuela
[2] Cent Univ Venezuela, Caracas, Venezuela
[3] Hosp Univ Caracas, Div Rheumatol, Ctr Nacl Enfermedades Reumat, Caracas, Venezuela
来源：
INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2004年 / 23卷 / 3-4期
关键词：
SLE; T cells; signaling; anergy;
D O I：
10.1080/08830180490452594-17
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Some of the signaling phenotypic abnormalities observed in peripheral blood T cells from patients with systemic lupus erythematosus resemble those seen in cells anergized by stimulation through the TCR/CD3 complex, in the absence of costimulatory signals, or by stimulation with altered ligands. The potential association of this "anergic" phenotype and the triggering of autoimmune responses in human lupus is discussed.
引用
收藏
页码：265 / 272
页数：8
相关论文
共 52 条
  • [1] DECREASED PRODUCTION OF AND RESPONSE TO INTERLEUKIN-2 BY CULTURED LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
    ALCOCERVARELA, J
    ALARCONSEGOVIA, D
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1982, 69 (06) : 1388 - 1392
  • [2] BHANDOOLA A, 1993, J IMMUNOL, V151, P2355
  • [3] Abnormal pattern of tyrosine phosphorylation in unstimulated peripheral blood T lymphocytes from patients with systemic lupus erythematosus
    Blasini, AM
    Alonzo, E
    Chacón, R
    Riera, R
    Stekman, IL
    Rodriguez, MA
    [J]. LUPUS, 1998, 7 (08) : 515 - 523
  • [4] Protein tyrosine kinase activity in T lymphocytes from patients with systemic lupus erythematosus
    Blasini, AM
    Brundula, V
    Paris, M
    Rivas, L
    Salazar, S
    Stekman, IL
    Rodriguez, MA
    [J]. JOURNAL OF AUTOIMMUNITY, 1998, 11 (05) : 387 - 393
  • [5] Boutin Y, 1997, J IMMUNOL, V159, P5802
  • [6] Brundula V, 1999, ARTHRITIS RHEUM-US, V42, P1908, DOI 10.1002/1529-0131(199909)42:9<1908::AID-ANR17>3.0.CO
  • [7] 2-7
  • [8] Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus:: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells
    Cedeño, S
    Cifarelli, DF
    Blasini, AM
    Paris, M
    Placeres, F
    Alonso, G
    Rodriguez, MA
    [J]. CLINICAL IMMUNOLOGY, 2003, 106 (01) : 41 - 49
  • [9] Floating the raft hypothesis: Lipid rafts play a role in immune cell activation
    Cherukuri, A
    Dykstra, M
    Pierce, SK
    [J]. IMMUNITY, 2001, 14 (06) : 657 - 660
  • [10] Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis
    Combadiere, B
    Freedman, M
    Chen, L
    Shores, EW
    Love, P
    Lenardo, MJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) : 2109 - 2117
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