Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias

被引:26
作者
Ballabio, E. [1 ,2 ,3 ]
Cantarella, C. D. [4 ]
Federico, C. [4 ]
Di Mare, P. [4 ,5 ]
Hall, G. [6 ]
Harbott, J. [7 ]
Hughes, J. [8 ]
Saccone, S. [4 ]
Tosi, S. [1 ,2 ]
机构
[1] Brunel Univ, Div Biosci, Ctr Cell & Chromosome Biol, London, England
[2] Brunel Univ, Brunel Inst Canc Genet & Pharmacogenom, London, England
[3] John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England
[4] Univ Catania, Dept Anim Biol M La Greca, Catania, Italy
[5] Univ Catania, Dept Paediat, Catania, Italy
[6] John Radcliffe Hosp, Oxford Childrens Hosp, Paediat Haematol Oncol Unit, Oxford OX3 9DU, England
[7] Univ Giessen, Oncogenet Lab, Dept Pediat Hematol & Oncol, Giessen, Germany
[8] Univ Oxford, MRC Dept Mol Haematol, Weatherall Inst Mol Med, Oxford, England
关键词
INFANT; ETV6; T(7/12)(Q36; P13);
D O I
10.1038/leu.2009.15
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:1179 / 1182
页数:5
相关论文
共 10 条
[1]  
Beverloo HB, 2001, CANCER RES, V61, P5374
[2]   Perturbations of chromatin structure in human genetic disease: recent advances [J].
Bickmore, WA ;
van der Maarel, SM .
HUMAN MOLECULAR GENETICS, 2003, 12 :R207-R213
[3]   Chromosome territories, nuclear architecture and gene regulation in mammalian cells [J].
Cremer, T ;
Cremer, C .
NATURE REVIEWS GENETICS, 2001, 2 (04) :292-301
[4]   The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density [J].
Federico, Concetta ;
Cantarella, Catia Daniela ;
Di Mare, Patrizia ;
Tosi, Sabrina ;
Saccone, Salvatore .
CHROMOSOMA, 2008, 117 (04) :399-410
[5]  
Tosi S, 2000, GENE CHROMOSOME CANC, V29, P325, DOI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1039>3.0.CO
[6]  
2-9
[7]  
Tosi S, 1998, GENE CHROMOSOME CANC, V21, P223, DOI 10.1002/(SICI)1098-2264(199803)21:3<223::AID-GCC6>3.0.CO
[8]  
2-1
[9]   Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemia [J].
Tosi, S ;
Hughes, J ;
Scherer, SW ;
Nakabayashi, K ;
Harbott, J ;
Haas, OA ;
Cazzaniga, G ;
Biondi, A ;
Kempski, H ;
Kearney, L .
GENES CHROMOSOMES & CANCER, 2003, 38 (02) :191-200
[10]   High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9 [J].
von Bergh, Anne R. M. ;
van Drunen, Ellen ;
van Wering, Elisabeth R. ;
van Zutven, Laura J. C. M. ;
Hainmann, Ina ;
Loennerholm, Gudmar ;
Meijerink, Jules P. ;
Pieters, Rob ;
Beverloo, H. Berna .
GENES CHROMOSOMES & CANCER, 2006, 45 (08) :731-739