Chemotherapy in the treatment of malignant gliomas

被引：28

作者：

Stem, Jennifer I. ^{[1
]}

Raizer, Jeffrey J. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2006年 / 6卷 / 05期

关键词：

anaplastic astrocytoma; chemotherapy; glioblastoma; malignant glioma; radiation therapy;

D O I：

10.1586/14737140.6.5.755

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Malignant gliomas are one of the most difficult tumors to treat, with only modest advances being made in the past few decades. Surgery and radiation have had the greatest impact, increasing survival. Chemotherapy modestly increases survival. The use of chemotherapy in the treatment of malignant gliomas is the focus of this paper and the more commonly used agents at diagnosis and relapse are reviewed. Since most patients fall first-, second- and even third-line agents that are commercially available, some of the more relevant new biological compounds will also be discussed. As treatments for brain tumors evolve, it is likely that optimal therapies will come from combination therapies that incorporate target-specific and chemotherapeutic agents.

引用

页码：755 / 767

页数：13

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