The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)

被引：31

作者：

Calligaro, DO

Fairhurst, J

Hotten, TM

Moore, NA

Tupper, DE

机构：

[1] ELI LILLY & CO,LILLY RES CTR LTD,WINDLESHAM GU20 6PH,SURREY,ENGLAND

[2] LILLY CORP CTR,LILLY RES LABS,INDIANAPOLIS,IN 46285

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(96)00567-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4'-N-desmethyl olanzapine (2), olanzapine 4'-N-oxide (3) and 2-hydroxymethyl olanzapine (5), have been prepared and their pharmacology compared to that of the parent compound olanzapine (1). The 4'-N-quaternary glucuronide (8) has also been prepared. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：25 / 30

页数：6

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