Some scaling principles for the immune system

被引：44

作者：

Wiegel, FW

Perelson, AS

机构：

[1] Univ Amsterdam, Inst Theoret Phys, NL-1018 XE Amsterdam, Netherlands

[2] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2004年 / 82卷 / 02期

关键词：

protectons; scaling laws; theoretical immunology;

D O I：

10.1046/j.0818-9641.2004.01229.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Using recent progress in biological scaling, we explore the way in which the immune system of an animal scales with its mass (M). It is shown that the number of cells in a single clone of B cells should scale as M and that the B-cell repertoire scales as ln (cM), where c is a constant. The time that a B cell needs to circulate once through the organism is shown to scale as M-1/4 ln (cM). It is suggested that the scaling of other cell populations in the immune system could be derived from these scaling relations for B cells.

引用

页码：127 / 131

页数：5

共 14 条

[1] A direct estimate of the human αβ T cell receptor diversity [J].