Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane

被引：94

作者：

Oghalai, JS ^{[1
]}

Zhao, HB ^{[1
]}

Kutz, JW ^{[1
]}

Brownell, WE ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Otolaryngol & Commun Sci, Houston, TX 77030 USA

来源：

SCIENCE | 2000年 / 287卷 / 5453期

关键词：

D O I：

10.1126/science.287.5453.658

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mechanism responsible for electromotility of outer hair cells in the ear is unknown but is thought to reside within the plasma membrane. Lipid Lateral diffusion in the outer hair fell plasma membrane is a sigmoidal function of transmembrane potential and bathing media osmolality. Cell depolarization or hyposmotic challenge shorten the cell and reduce membrane fluidity by half. Changing the membrane tension with amphipathic drugs results in similar reductions. These dynamic changes in membrane fluidity represent the modulation of membrane tension by lipid-protein interactions. The voltage dependence may be associated with the force-generating motors that contribute to the exquisite sensitivity of mammalian hearing.

引用

页码：658 / 661

页数：4

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