The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

被引：340

作者：

Stevens, Emily A. ^{[1
]}

Mezrich, Joshua D. ^{[1
]}

Bradfield, Christopher A. ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA

来源：

IMMUNOLOGY | 2009年 / 127卷 / 03期

基金：

美国国家卫生研究院;

关键词：

aryl hydrocarbon receptor; dioxin; immune function; thymus; T lymphocytes; REGULATORY T-CELLS; POLYCYCLIC AROMATIC-HYDROCARBONS; ABNORMAL LIVER DEVELOPMENT; AH-RECEPTOR; DIOXIN RECEPTOR; IN-VITRO; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD; GENE-EXPRESSION; LIGAND-BINDING; TRANSIENT INDUCTION;

D O I：

10.1111/j.1365-2567.2009.03054.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aryl hydrocarbon receptor (AHR) is a protein best known for its role in mediating toxicity. Over 30 years of research has uncovered additional roles for the AHR in xenobiotic metabolism and normal vascular development. Activation of the AHR has long been known to cause immunotoxicity, including thymic involution. Recent data suggesting a role for the AHR in regulatory T-cell (Treg) and T-helper 17 (Th17) cell development have only added to the excitement about this biology. In this review, we will attempt to illustrate what is currently known about AHR biology in the hope that data from fields as diverse as evolutionary biology and pharmacology will help elucidate the mechanism by which AHR modifies immune responses. We also will discuss the complexities of AHR pharmacology and genetics that may influence future studies of AHR in the immune system.

引用

页码：299 / 311

页数：13

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