Effect of estradiol on phospholipid lipoprotein levels and fatty acid composition in the rat

Phospholipid content and fatty acid composition in the different serum lipoproteins showed specific variations after castration and estradiol administration. Only the levels of phospholipids in HDL, the principal lipoprotein carrying phospholipids, increased after castration and were further enhanced by estradiol treatment, especially at low doses. Fatty acid composition showed many variations and an irregular pattern. The EFA/NEFA, EFA/ME and SAT/ME ratios were calculated. EFA/ME increased in VLDL after both doses of estradiol, while EFA/NEFA and EFA/ME of LDL enhanced at the low dose and decreased at the high one in a dose-dependent manner. HDL showed higher EFA/ME and SAT/ME ratios after castration and lower values of all ratios after both doses of estradiol. The correlation with diseases more frequent in men is discussed.