Correlation of neuropilin-1 overexpression to survival in acute myeloid leukemia

被引：55

作者：

Kreuter, M. ^{[1
]}

Woelke, K. ^{[1
]}

Bieker, R. ^{[1
]}

Schliemann, C. ^{[1
]}

Steins, M. ^{[1
]}

Buechner, T. ^{[1
]}

Berdel, W. E. ^{[1
]}

Mesters, R. M. ^{[1
]}

机构：

[1] Univ Hosp Munster, Dept Med Hematol & Oncol, D-48129 Munster, Germany

来源：

LEUKEMIA | 2006年 / 20卷 / 11期

关键词：

neuropilin; angiogenesis; acute myeloid leukemia;

D O I：

10.1038/sj.leu.2404384

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuropilin-1 (NRP-1), a vascular endothelial growth factors and semaphorin receptor functioning as mediator of angiogenesis and neuronal guidance, is expressed by various solid tumors. The importance of NRP-1 in hematological malignancies such as acute myeloid leukemia (AML) remains to be elucidated. Therefore, we determined NRP-1 expression by immunohistochemical analysis of bone marrow biopsies of patients with newly diagnosed, untreated AML. The expression of NRP-1 was significantly increased in AML patients (n = 76; median 12.9 arbitrary units (a.u.)) as compared with controls ( n 38; median 2.75 a.u.). Survival was significantly poorer in patients with high (> median) versus low (<= median) NRP-1 expression levels with 5-year overall survival rates of 16.9 versus 49.6% ( P = 0.050). In conclusion, our data provide evidence of increased NRP-1 expression in AML with significant correlation to survival. Thus, NRP-1 might constitute a promising target for antileukemic and antiangiogenic treatment strategies in AML.

引用

页码：1950 / 1954

页数：5

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