Altered brain activation during response inhibition in obstructive sleep apnea

被引：43

作者：

Ayalon, Liat ^{[1
,2
]}

Ancoli-Israel, Sonia ^{[1
,2
]}

Drummond, Sean Pa ^{[1
,3
]}

机构：

[1] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[2] Vet Affairs San Diego Healthcare Syst, Res Serv, San Diego, CA USA

[3] Vet Affairs San Diego Healthcare Syst, Psychol Serv, San Diego, CA USA

来源：

JOURNAL OF SLEEP RESEARCH | 2009年 / 18卷 / 02期

关键词：

brain activation; functional magnetic resonance imaging; obstructive sleep apnea; response inhibition; sleep; INDIVIDUAL-DIFFERENCES; WORKING-MEMORY; NEURAL BASIS; FMRI; DEPRIVATION; TASK; METAANALYSIS; HEALTH;

D O I：

10.1111/j.1365-2869.2008.00707.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.

引用

页码：204 / 208

页数：5

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