Heat shock factors and the control of the stress response

被引:456
作者
Santoro, MG
机构
[1] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[2] CNR, Inst Expt Med, I-00133 Rome, Italy
关键词
antiviral; cyclopentenone; heat shock factor; heat shock proteins; heat shock response; NF-kappa B; prostaglandins;
D O I
10.1016/S0006-2952(99)00299-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Living cells are continually challenged by conditions which cause acute and chronic stress. To adapt to environmental changes and survive different types of injuries, eukaryotic cells have evolved networks of different responses which detect and control diverse forms of stress. One of these responses, known as the heat shock response, has attracted a great deal of attention as a universal fundamental mechanism necessary for cell survival under a variety of unfavorable conditions. In mammalian cells, the induction of the heat shock response requires the activation and translocation to the nucleus of one or more heat shock transcription factors which control the expression of a specific set of genes encoding cytoprotective heat shock proteins. The discovery that the heat shock response is turned on under several pathological conditions and contributes to establish a cytoprotective state in a variety of human diseases, including ischemia, inflammation, and infection, has opened new perspectives in medicine and pharmacology, as molecules activating this defense mechanism appear as possible candidates for novel cytoprotective drugs. This article focuses on the regulation and function of the heat shock response in mammalian cells and discusses the molecular mechanisms involved in its activation by stress and bioactive cyclopentenone prostanoids, as well as its interaction with nuclear factor KB, a stress-regulated transcription factor with a pivotal role in inflammation and immunity. BIOCHEM PHARMACOL 59;1:55-63, 2000. (C) 1999 Elsevier Science Inc.
引用
收藏
页码:55 / 63
页数:9
相关论文
共 69 条
[1]   SELECTIVE-INHIBITION OF VIRUS PROTEIN-SYNTHESIS BY PROSTAGLANDIN A(1) - A TRANSLATIONAL BLOCK ASSOCIATED WITH HSP70 SYNTHESIS [J].
AMICI, C ;
GIORGI, C ;
ROSSI, A ;
SANTORO, MG .
JOURNAL OF VIROLOGY, 1994, 68 (11) :6890-6899
[2]  
AMICI C, 1995, CANCER RES, V55, P4452
[3]   ANTIPROLIFERATIVE PROSTAGLANDINS ACTIVATE HEAT-SHOCK TRANSCRIPTION FACTOR [J].
AMICI, C ;
SISTONEN, L ;
SANTORO, MG ;
MORIMOTO, RI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6227-6231
[4]   INDUCTION OF THERMOTOLERANCE BY PROSTAGLANDIN-A IN HUMAN-CELLS [J].
AMICI, C ;
PALAMARA, AT ;
SANTORO, MG .
EXPERIMENTAL CELL RESEARCH, 1993, 207 (02) :230-234
[5]   KEY FEATURES OF HEAT-SHOCK REGULATORY ELEMENTS [J].
AMIN, J ;
ANANTHAN, J ;
VOELLMY, R .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) :3761-3769
[6]   IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF NF-KAPPA-B ACTIVITY THROUGH INDUCTION OF I-KAPPA-B SYNTHESIS [J].
AUPHAN, N ;
DIDONATO, JA ;
ROSETTE, C ;
HELMBERG, A ;
KARIN, M .
SCIENCE, 1995, 270 (5234) :286-290
[7]   The NF-kappa B and I kappa B proteins: New discoveries and insights [J].
Baldwin, AS .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683
[8]   Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases [J].
Barnes, PJ ;
Larin, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) :1066-1071
[9]  
Cotto JJ, 1996, J BIOL CHEM, V271, P3355
[10]   Induction of the heat-shock response by antiviral prostaglandins in human cells infected with human immunodeficiency virus type 1 [J].
De Marco, A ;
Carattoli, A ;
Rozera, C ;
Fortini, D ;
Giorgi, C ;
Belardo, G ;
Amici, C ;
Santoro, MG .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 256 (02) :334-341