A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL

被引：251

作者：

Philipp, S ^{[1
]}

Cavalie, A ^{[1
]}

Freichel, M ^{[1
]}

Wissenbach, U ^{[1
]}

Zimmer, S ^{[1
]}

Trost, C ^{[1
]}

Marquart, A ^{[1
]}

Murakami, M ^{[1
]}

Flockerzi, V ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST PHARMAKOL,D-69120 HEIDELBERG,GERMANY

来源：

EMBO JOURNAL | 1996年 / 15卷 / 22期

关键词：

calcium signalling; calcium spiking; capacitative calcium entry; InsP(3) signalling; store depletion;

D O I：

10.1002/j.1460-2075.1996.tb01004.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP(3))-mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry, Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP(3) or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP(3) signalling.

引用

页码：6166 / 6171

页数：6

共 32 条

[1] CLOTRIMAZOLE INHIBITS CELL-PROLIFERATION IN-VITRO AND IN-VIVO
BENZAQUEN, LR
BRUGNARA, C
BYERS, HR
GATTONICELLI, S
HALPERIN, JA
[J]. NATURE MEDICINE, 1995, 1 (06) : 534 - 540
[2] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING
BERRIDGE, MJ
[J]. NATURE, 1993, 361 (6410) : 315 - 325
[3] ROLE OF THE CAPACITATIVE CALCIUM INFLUX IN THE ACTIVATION OF STEROIDOGENESIS BY ANGIOTENSIN-II IN ADRENAL GLOMERULOSA CELLS
BURNAY, MM
PYTHON, CP
VALLOTTON, MB
CAPPONI, AM
ROSSIER, MF
[J]. ENDOCRINOLOGY, 1994, 135 (02) : 751 - 758
[4] CONTROL OF CA2+ ENTRY INTO RAT LACTOTROPHS BY THYROTROPIN-RELEASING-HORMONE
CAREW, MA
MASON, WT
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1995, 486 (02): : 349 - 360
[5] GREEN FLUORESCENT PROTEIN AS A MARKER FOR GENE-EXPRESSION
CHALFIE, M
TU, Y
EUSKIRCHEN, G
WARD, WW
PRASHER, DC
[J]. SCIENCE, 1994, 263 (5148) : 802 - 805
[6] CHARACTERIZATION OF SPONTANEOUS CALCIUM TRANSIENTS IN NERVE GROWTH CONES AND THEIR EFFECT ON GROWTH CONE MIGRATION
GOMEZ, TM
SNOW, DM
LETOURNEAU, PC
[J]. NEURON, 1995, 14 (06) : 1233 - 1246
[7] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES
HAMILL, OP
MARTY, A
NEHER, E
SAKMANN, B
SIGWORTH, FJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02): : 85 - 100
[8] THE TRP GENE IS ESSENTIAL FOR A LIGHT-ACTIVATED CA2+ CHANNEL IN DROSOPHILA PHOTORECEPTORS
HARDIE, RC
MINKE, B
[J]. NEURON, 1992, 8 (04) : 643 - 651
[9] A FUNCTIONAL CONNECTION BETWEEN THE PORES OF DISTANTLY RELATED ION CHANNELS AS REVEALED BY MUTANT K+ CHANNELS
HEGINBOTHAM, L
ABRAMSON, T
MACKINNON, R
[J]. SCIENCE, 1992, 258 (5085) : 1152 - 1155
[10] HILLE B, 1992, IONIC CHANNELS EXCIT, P226

← 1 2 3 4 →