A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL

被引:251
作者
Philipp, S [1 ]
Cavalie, A [1 ]
Freichel, M [1 ]
Wissenbach, U [1 ]
Zimmer, S [1 ]
Trost, C [1 ]
Marquart, A [1 ]
Murakami, M [1 ]
Flockerzi, V [1 ]
机构
[1] UNIV HEIDELBERG,INST PHARMAKOL,D-69120 HEIDELBERG,GERMANY
关键词
calcium signalling; calcium spiking; capacitative calcium entry; InsP(3) signalling; store depletion;
D O I
10.1002/j.1460-2075.1996.tb01004.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP(3))-mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry, Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP(3) or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP(3) signalling.
引用
收藏
页码:6166 / 6171
页数:6
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