In vivo and in vitro investigations into the biosynthetic relatedness of the pseudopterosins

被引：15

作者：

Coleman, AC ^{[1
]}

Mydlarz, LD ^{[1
]}

Kerr, RG ^{[1
]}

机构：

[1] Florida Atlantic Univ, Dept Chem & Biochem, Ctr Mol Biol & Biotechnol, Boca Raton, FL 33431 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 13期

关键词：

D O I：

10.1021/ol991120i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both in vivo and in vitro techniques have been developed to test putative intermediates in the biosynthetic pathway to the pseudopterosins, antiinflammatory compounds isolated from Pseudopterogorgia elisabethae, Furthermore, specific activity data we have obtained indicate that pseudopterosin A is a precursor to pseudopterosins B, C, and D, We conclude that in the biosynthesis xylose is attached to the diterpene skeleton to produce pseudopterosin A and is then aceylated to form pseudopterosins B-D.

引用

页码：2173 / 2175

页数：3

共 5 条

[1]

ETTOUATI WS, 1987, MOL PHARMACOL, V31, P500

[2]

HAIMES HB, 1995, INFLAMMATION RES S, V44

[3] THE PSEUDOPTEROSINS - ANTIINFLAMMATORY AND ANALGESIC NATURAL-PRODUCTS FROM THE SEA WHIP PSEUDOPTEROGORGIA-ELISABETHAE [J].

LOOK, SA ;

FENICAL, W ;

JACOBS, RS ;

CLARDY, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (17) :6238-6240

[4] THE PSEUDOPTEROSINS - A NEW CLASS OF ANTIINFLAMMATORY AND ANALGESIC DITERPENE PENTOSIDES FROM THE MARINE SEA WHIP PSEUDOPTEROGORGIA-ELISABETHAE (OCTOCORALLIA) [J].

LOOK, SA ;

FENICAL, W ;

MATSUMOTO, GK ;

CLARDY, J .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (26) :5140-5145

[5] NEW ANTIINFLAMMATORY PSEUDOPTEROSINS FROM THE MARINE OCTOCORAL PSEUDOPTEROGORGIA-ELISABETHAE [J].

ROUSSIS, V ;

WU, ZD ;

FENICAL, W ;

STROBEL, SA ;

VANDUYNE, GD ;

CLARDY, J .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (16) :4916-4922

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