The urocortins: Mechanisms of cardioprotection and therapeutic potential

被引：13

作者：

Lawrence, K. M. ^{[1
]}

Latchman, D. S. ^{[1
]}

机构：

[1] UCL, Inst Child Hlth, Mol Biol Unit, London WC1E 6BT, England

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 10期

关键词：

corticotrophin-releasing hormone; urocortin; cardiac ischaemia and reperfusion injury; affymetrix gene chip microarrays; affective disorders; cardiomyocyte mitochondria;

D O I：

10.2174/138955706778560111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The study of the Urocortin family of peptides is becoming increasingly important clinically, as new discoveries have revealed that their roles in the body are extremely diverse. They range from being involved in the aetiology of affective disorders, boosting the immune system, to cardioprotection during ischaemia and reperfusion injury. Therefore, it is important to understand how these peptides become activated, how they activate different cell types and finally their intracellular signalling pathways. Such studies may enable scientists to develop clinical therapies based on their mechanism of action, which may be used to alleviate a diverse range of pathologies.

引用

页码：1119 / 1126

页数：8

共 99 条

[1] Protein kinase Cε interacts with and inhibits the permeability transition pore in cardiac mitochondria [J].

Baines, CP ;

Song, CX ;

Zheng, YT ;

Wang, GW ;

Zhang, J ;

Wang, OL ;

Guo, Y ;

Bolli, R ;

Cardwell, EM ;

Ping, PP .

CIRCULATION RESEARCH, 2003, 92 (08) :873-880

[2] Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: Role in neuronal excitability and associative learning [J].

Blank, T ;

Nijholt, I ;

Grammatopoulos, DK ;

Randeva, HS ;

Hillhouse, EW ;

Spiess, J .

JOURNAL OF NEUROSCIENCE, 2003, 23 (02) :700-707

[3] Mitochondria in apoptosis of ischemic heart [J].

Borutaite, V ;

Brown, GC .

FEBS LETTERS, 2003, 541 (1-3) :1-5

[4] Post-translational processing of human procorticotrophin-releasing factor in transfected mouse neuroblastoma and Chinese hamster ovary cell lines [J].

Brar, B ;

Sanderson, T ;

Wang, N ;

Lowry, PJ .

JOURNAL OF ENDOCRINOLOGY, 1997, 154 (03) :431-440

[5] Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway [J].

Brar, BK ;

Jonassen, AK ;

Stephanou, A ;

Santilli, G ;

Railson, J ;

Knight, RA ;

Yellon, DM ;

Latchman, DS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :8508-8514

[6] Urocortin-II and Urocortin-III are cardioprotective against ischemia reperfusion injury: An essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart [J].

Brar, BK ;

Jonassen, AK ;

Egorina, EM ;

Chen, A ;

Negro, A ;

Perrin, MH ;

Mjos, OD ;

Latchman, DS ;

Lee, KF ;

Vale, W .

ENDOCRINOLOGY, 2004, 145 (01) :24-35

[7] Urocortin increases the expression of heat shock protein 90 in rat cardiac myocytes in a MEK1/2-dependent manner [J].

Brar, BK ;

Railson, J ;

Stephanou, A ;

Knight, RA ;

Latchman, DS .

JOURNAL OF ENDOCRINOLOGY, 2002, 172 (02) :283-293

[8] Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death [J].

Brar, BK ;

Stephanou, A ;

Knight, R ;

Latchman, DS .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (04) :483-492

[9] CRH-like peptides protect cardiac myocytes from lethal ischaemic injury [J].

Brar, BK ;

Stephanou, A ;

Okosi, A ;

Lawrence, KM ;

Knight, RA ;

Marber, MS ;

Latchman, DS .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1999, 158 (1-2) :55-63

[10] Secondary structure of antisauvagine analogues is important for CRF receptor antagonism: development of antagonists with increased potency and receptor selectivity [J].

Brauns, O ;

Brauns, S ;

Jenke, M ;

Zimmermann, B ;

Dautzenberg, FM .

PEPTIDES, 2002, 23 (10) :1817-1827

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