Mechanisms of mitochondrial response to variations in energy demand in eukaryotic cells

被引:60
作者
Devin, Anne [1 ]
Rigoulet, Michel [1 ]
机构
[1] Univ Victor Segalen Bordeaux 2, CNRS, IBGC, UMR 5095, F-33077 Bordeaux, France
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2007年 / 292卷 / 01期
关键词
yeast; C6 glioma cells; muscle; kinetic regulation;
D O I
10.1152/ajpcell.00208.2006
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
This review focuses on the different mechanisms involved in the adjustment of mitochondrial ATP production to cellular energy demand. The oxidative phosphorylation steady state at constant mitochondrial enzyme content can vary in response to energy demand. However, such an adaptation is tightly linked to a modification in both oxidative phosphorylation yield and phosphate potential and is obviously very limited in eukaryotic cells. We describe the three main mechanisms involved in mitochondrial response to energy demand. In heart cells, a short-term adjustment can be reached mainly through metabolic signaling via phosphotransfer networks by the compartmentalized energy transfer and signal transmission. In such a complex regulatory mechanism, Ca2+ signaling participates in activation of matricial dehydrogenases as well as mitochondrial ATP synthase. These processes allow a large increase in ATP production rate without an important modification in thermodynamic forces. For a long-term adaptation, two main mechanisms are involved: modulation of the mitochondrial enzyme content as a function of energy demand and/or kinetic regulation by covalent modifications (phosphorylations) of some respiratory chain complex subunits. Regardless of the mechanism involved (kinetic regulation by covalent modification or adjustment of mitochondrial enzyme content), the cAMP signaling pathway plays a major role in molecular signaling, leading to the mitochondrial response. We discuss the energetic advantages of these mechanisms.
引用
收藏
页码:C52 / C58
页数:7
相关论文
共 53 条
  • [1] Yeast mitochondrial metabolism:: From in vitro to in situ quantitative study
    Avéret, N
    Fitton, V
    Bunoust, O
    Rigoulet, M
    Guérin, B
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 184 (1-2) : 67 - 79
  • [2] Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
    Baar, K
    Wende, AR
    Jones, TE
    Marison, M
    Nolte, LA
    Chen, M
    Kelly, DP
    Holloszy, JO
    [J]. FASEB JOURNAL, 2002, 16 (14) : 1879 - 1886
  • [3] Cardiac energy metabolism homeostasis: Role of cytosolic calcium
    Balaban, RS
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (10) : 1259 - 1271
  • [4] Calcium signalling: Dynamics, homeostasis and remodelling
    Berridge, MJ
    Bootman, MD
    Roderick, HL
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) : 517 - 529
  • [5] Cardiac excitation-contraction coupling
    Bers, DM
    [J]. NATURE, 2002, 415 (6868) : 198 - 205
  • [6] High cAMP levels antagonize the reprogramming of gene expression that occurs at the diauxic shift in Saccharomyces cerevisiae
    BoyMarcotte, E
    Tadi, D
    Perrot, M
    Boucherie, H
    Jacquet, M
    [J]. MICROBIOLOGY-UK, 1996, 142 : 459 - 467
  • [7] The phosphorylation of Subunits of complex I from bovine heart mitochondria
    Chen, RM
    Fearnley, IM
    Peak-Chew, SY
    Walker, JE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (25) : 26036 - 26045
  • [8] The yeast cAMP protein kinase Tpk3p is involved in the regulation of mitochondrial enzymatic content during growth
    Chevtzoff, C
    Vallortigara, J
    Avéret, N
    Rigoulet, M
    Devin, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2005, 1706 (1-2): : 117 - 125
  • [9] An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics
    Cortassa, S
    Aon, MA
    Marbán, E
    Winslow, RL
    O'Rourke, B
    [J]. BIOPHYSICAL JOURNAL, 2003, 84 (04) : 2734 - 2755
  • [10] Growth of the yeast Saccharomyces cerevisiae on a non-fermentable substrate:: control of energetic yield by the amount of mitochondria
    Dejean, L
    Beauvoit, B
    Guérin, B
    Rigoulet, M
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2000, 1457 (1-2): : 45 - 56