Synthesis of arylpiperazines via nucleophilic aromatic substitution of (eta(6)-fluoroarene)tricarbonylchromium complexes

被引：18

作者：

Perez, M

Potier, P

Halazy, S

机构：

[1] Div. de Chimie Médicinale IV, Centre de Recherche Pierre Fabre, 81106 Castres Cédex

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 47期

关键词：

D O I：

10.1016/0040-4039(96)01971-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, high yield preparation procedure for the synthesis of arylpiperazines using a nucleophilic aromatic substitution of (eta(6)-fluoroarene)tricarbonyl chromium complexes (including those bearing electron donating groups) is described. A new, easy and fast decomplexation procedure, in DMSO as solvent, is also presented. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8487 / 8488

页数：2

共 6 条

[1] NUCLEOPHILIC DISPLACEMENTS OF ACTIVATED FLUORINE IN AROMATIC COMPOUNDS
BADER, H
HANSEN, AR
MCCARTY, FJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (07) : 2319 - &
[2] Mahaffy C.A.L., 1979, Inorganic Syntheses, P154
[3] Formation of phenylpiperazines by a novel alumina supported bis-alkylation.
Mishani, E
Dence, CS
McCarthy, TJ
Welch, MJ
[J]. TETRAHEDRON LETTERS, 1996, 37 (03) : 319 - 322
[4] NICHOLLS B, 1971, J ORG CHEM, V36, P4081
[5] SYNTHESIS AND SEROTONERGIC ACTIVITY OF ARYLPIPERAZIDE DERIVATIVES OF SEROTONIN - POTENT AGONISTS FOR 5-HT1D RECEPTORS
PEREZ, M
FOURRIER, C
SIGOGNEAU, I
PAUWELS, PJ
PALMIER, C
JOHN, GW
VALENTIN, JP
HALAZY, S
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (18) : 3602 - 3607
[6] Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines
Zhao, SH
Miller, AK
Berger, J
Flippin, LA
[J]. TETRAHEDRON LETTERS, 1996, 37 (26) : 4463 - 4466

← 1 →